Brought to life by the miracle of DNA cloning, a 93-foot Megalodon shark has escaped captivity. With an insatiable appetite and unmatched aggression, it travels west for the Georgia coast, leaving a path of destruction in its wake. Bullets and harpoons can’t penetrate it, steel nets can’t hold it, and it’s only a matter of time before the whole world finds out about it.
In a race to stop the beast, the organization responsible recruit a marine biologist and a herpetologist to develop a plan to catch it. To do it, they must unleash the company’s other genetically modified experiment—a 150-foot snake, resurrected from the DNA of the mighty Titanoboa.
The pursuit leads to inevitable combat, and the scientists are forced to witness the deadly realities of genetic tampering. As the battle escalates, it is clear nobody is safe…and that nature never intended for these beasts to return. As the destruction mounts, and the death toll climbs, the true loser of Megalodon vs. Colossal Snake is humanity.
